If one would observe the smooth ER and peroxisomes of an alcoholic person, there would be a difference in appearance. The liver is filled with cells with high activities of smooth ER and peroxisomes. The reason is to help the liver fulfill its detoxifying function in the human body. Smooth ER contains enzymes that degrade inorganic toxins. Meanwhile, peroxisomes use catalases to transfer the hydrogen from toxins to free O2 molecules. The byproducts of detoxification processes can accumulate in the liver. Alcohol can cause the accumulation of scar tissue in the liver. If you would observe the liver cells of an alcoholic person you would see damaged cells, and areas of the liver are filled with scar tissues.