You do not consume alcoholic beverages, but your friend does, and he consumes these drinks regularly and in large amounts. If we could examine your liver cells and compare with your friend, would we see a difference in smooth ER and peroxisomes?
For a short background, alcohol that is uptaken into our system is processed and metabolized in our livers. In our liver, cells detoxify them through specific organelles such as the smooth endoplasmic reticulum and the peroxisome. Through both organelles, alcohol is oxidized and broken down.
Now if we examine and compare the liver cells of my friend who is a regular alcohol drinker to mine who does not consume alcohol, we can see a huge difference in the shape and overall structure of the cell. His liver cells will be hypertrophied and irregular in shape. His smooth ER and peroxisomes would be so worked out due to the influx of alcohol to oxidize, which can potentially lead to the partial or total malfunction and damage of these organelles. Thus, inhibiting the detoxification of alcohol which can damage his liver cells and eventually his liver. As to my liver cells, they are healthy and both the smooth ER and peroxisome are in optimal condition to fulfill their designated tasks. In conclusion, my liver would be healthier than his.