You do not consume alcoholic beverages, but your friend does, and he consumes these drinks regularly and in large amounts. If we could examine your liver cells and compare them with your friend, would we see a difference in smooth ER and peroxisomes?
Peroxisomes and smooth ER are more abundant in liver cells. Peroxisomes oxidize toxic substances, while smooth ER detoxify them. These substances include alcohol. So if too much alcohol is consumed, there would be a difference in the structure of these organelles.
When a person consumes too much alcohol, there will be too much pathological stress on these organelles. For the ER, it may cause incapability in protein folding that may cause cell death if not treated. While too much alcohol affects our peroxisome's capability to oxidize the substance, it may cause a build-up of toxic substances that may cause certain diseases in different areas of our body. The number of these organelles in our cells would also decrease, making the digestion of these substances very slow.
References:
Bradford, B. U. (2007, June). Role of peroxisomes in the swift increase in alcohol metabolism. National Library of Medicine. Retrieved September 14, 2022, from https://pubmed.ncbi.nlm.nih.gov/17567460/
Howarth, D. L., Vacaru, A. M., Tsedensodnom, O., Mormone, E., Nieto, N., Costantini, L. M., Snapp, E. L., & Sadler, K. C. (2012, January). Alcohol disrupts endoplasmic reticulum function and protein secretion in hepatocytes. National Library of Medicine. Retrieved September 14, 2022, from https://pubmed.ncbi.nlm.nih.gov/21790674/