The smooth endoplasmic reticulum and the peroxisomes are both responsible for synthesizing lipids and alcohol detoxification. With the alcohol consumption of my friend, the smooth endoplasmic reticulum and peroxisomes in the liver cells may undergo unfolding or misfolding of proteins, and appearance and activity alterations. This will then contribute to conditions in the major organs, especially the liver. Comparing it to my liver cells, particularly its smooth endoplasmic reticulum and peroxisomes, are healthier and well-functioning.