If my liver cells and that of my alcoholic friend are compared, we will be able to see a difference in the health of our cells. As excessive alcoholism puts our body under pathological stress responses, my friend's endoplasmic reticulum and peroxisomes would have impaired functions. Particularly in the endoplasmic reticulum whose stress response involves the accumulation of misfolded proteins. On the other hand, my liver cells would be well-functioning and healthy.