If we could examine my liver cells and compare it with my friend, my liver cells would be healthier than his/her. Drinking alcoholic beverages, especially if done regularly and in excessive amounts, triggers the endoplasmic reticulum (ER) stress respond, which causes misfolded or unfolded protein to build up and cause further complications. We would also see a significant difference between the number of smooth ER and peroxisomes present in our cells; he would have (and need) more in order to oxidize the alcohol.