You do not consume alcoholic beverages, but your friend does, and he consumes these drinks regularly and in large amounts, If we could examine your liver cells and compare with your friend, would we see a difference in smooth ER and peroxisomes?
Given that my friend consumes large amounts of alcoholic beverages regularly, there is no doubt that there are differences in our bodies, especially in the anatomy of our liver. To be more particular, my friend is likely to have a larger amount of smooth ER and peroxisomes in his liver cells since his system may have detected the need for more of these to maintain enough enzymatic function, and to control the levels of toxins in his blood, which is caused by the alcohol.