You do not consume alcoholic beverages, but your friend does, and he consumes these drinks regularly and in large amounts. If we could examine your liver cells and compare with your friend, would we see a difference in smooth ER and peroxisomes?
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The liver is responsible for breaking down the alcohol in these beverages, so excessive alcohol consumption can seriously damage the organ, the worst case would be death and organ failure. The smooth ER and peroxisome might also fail if they exhaust too much energy in detoxifying these harmful compounds regularly and in huge amounts. Alcohol also causes disruption in the reproduction and growth of these cells and cell organelles, in general.