You do not consume alcoholic beverages, but your friend does, and he consumes these drinks regularly and in large amounts. if we could examine your liver cells and compare with your friend, would we see a difference in smooth ER and peroxisomes?
The smooth endoplasmic reticulum is responsible for digesting and synthesizing lipids and proteins. It is also responsible for detoxifying the cell. Peroxisomes serve as an antioxidant, defending the liver against free radicals produced when free fatty acids and protein are broken down. They are tiny, layer-encased organelles that contain chemicals involved in a variety of metabolic processes, including the digestion of nutrients. Despite sharing a similar morphology to lysosomes, peroxisomes are formed from proteins that are integrated on free ribosomes and then transported into peroxisomes as complete polypeptide chains, just like mitochondria and chloroplasts.
Since the smooth endoplasmic reticulum inactivates or detoxifies drugs, and peroxisomes likewise annihilate unsafe substances, my friend who consumes alcohol on a daily basis will have expanded quantities of these organelles in his/her liver.