You do not consume alcoholic beverages, but your friend does, and he consumes these drinks regularly and in large amounts. If we could examine your liver cells and compare with your friend, would we see a difference in smooth ER and peroxisomes?
Given that the smooth ER helps in inactivating and detoxifying like alcohol, and peroxisomes destroy potentially harmful substances like alcohol, I think that we would see a difference in the liver cells of me and my friend. Since they regularly consume alcohol in large amounts, there would be an increased number of smooth ER and peroxisomes in their liver cells.