You do not consume alcoholic beverages, but your friend does, and he consumes these drinks regularly and in large amounts, If we could examine your liver cells and compare with your friend, would we see a difference in smooth ER and peroxisomes?
One of the functions of the smooth endoplasmic reticulum is drug detoxifier. Similarly, peroxisomes oxidizes toxic substances, alcohol, for example. If I, who does not drink alcohol, were to be compared to my alcoholic friend's smooth ER and peroxisomes, there would be a vast difference between the two. To accommodate the excessive alcohol intake, my friend would have an increase in smooth ER and peroxisomes. Thus, there would be a greater chance of an alcoholic disorder. On the contrary, I would have fewer chances of having these disorders as my smooth ER and peroxisomes would function like usual without putting much effort into detoxifying toxic substances in my body.