Yes, since smooth ER and peroxisomes are both abundant in the liver cells. First, with the smooth ER, which detoxifies potentially harmful substances like alcohol. Individuals who repeatedly take such, develop changes in the smooth ER in their liver cells. With repeated alcohol exposure, the amount of smooth ER and its enzymes rises to protect the cell from the drug's harmful effects. As the proportion of smooth ER rises, more amounts of the medicine are required to produce the original effect. This could lead to an increased risk of increasing alcohol dependence. As for the peroxisomes, it also has enzymes that oxidize toxic substances, such as alcohol.
With that, there would be visible changes in both our liver cells. Because too much alcohol consumption can lead to hepatitis or inflammation of the liver, which would be evident in my friend's liver cells.
Reference:
Ji, C. (2012). Mechanisms of Alcohol-Induced Endoplasmic Reticulum Stress and Organ Injuries. 2 Biochemistry Research International, 2012. https://doi.org/10.1155/2012/216450