Excessive alcohol consumption induces the endoplasmic reticulum stress response, a condition where unfolded or misfolded proteins accumulate in the endoplasmic reticulum due to a disruption in the protein folding capability of the endoplasmic reticulum and is implicated in hepatocyte lipid accumulation and apoptosis, which are associated with alcoholic liver disease (ALD). Potential mechanisms that trigger this condition are directly or indirectly linked to alcohol consumption such as the process of toxic acetaldehyde. Alcoholics also have more peroxisomes than those who do not drink alcohol much.