If need for reversal of non-depolarizing neuromuscular blocker activity arises, is there a preferred agent between sugammadex and acetylcholinesterase inhibitors?
Reversal of Non-Depolarizing Neuromuscular Blocking Agents
by Stephanie Paredes -
Number of replies: 1
In reply to Stephanie Paredes
Re: Reversal of Non-Depolarizing Neuromuscular Blocking Agents
by Karel Ann Espejo -
Hi, Stephanie!
It depends on a case to case basis. Suggamadex causes less side effects than acetylcholinesterase inhibitors, can be used even during deep levels of blockade, but it is much much more expensive and is only indicated for reversal of rocuronium. In addition, some patients may be allergic to it. On the other hand, acetylcholinesterase inhibitors are cheaper, will reverse all nondepolarizing agents but has cholinergic side effects and will not work during deep blockade.
It depends on a case to case basis. Suggamadex causes less side effects than acetylcholinesterase inhibitors, can be used even during deep levels of blockade, but it is much much more expensive and is only indicated for reversal of rocuronium. In addition, some patients may be allergic to it. On the other hand, acetylcholinesterase inhibitors are cheaper, will reverse all nondepolarizing agents but has cholinergic side effects and will not work during deep blockade.
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