You do not consume alcoholic beverages, but your friend does, and he consumes these drinks regularly and in large amounts. If we could examine your liver cells and compare with your friend, would we see a difference in smooth ER and peroxisomes?
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Yes, there would be a difference as alcohol consumption can cause pathological changes. Compared to mine, my friend’s smooth endoplasmic reticulum might be at stress, which can result in the unfolding/misfolding of the said organelle. And in terms of peroxisomes, I’m not entirely sure but I think that there are more peroxisomes evident in the liver cell of my alcoholic friend since this organelle is responsible for the detoxification of the alcohol intake through oxidation.