You do not consume alcoholic beverages, but your friend does, and he consumes these drinks regularly and in large amounts. If we could examine your liver cells and compare with your friend, would we see a difference in smooth ER and peroxisomes?
Alcohol is an inorganic toxin that is detoxified by smooth endoplasmic reticulum; hence, more smooth ER can be detected in the liver cells of persons who consume alcoholic beverages as a response to the increased amount of alcohol that they need to process. Peroxisomes work in a similar manner. An increase in peroxisomes is evident since they oxidize poisonous compounds like alcohol.