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Unlike in other gut regions, expression of hedgehog signaling during pancreatic development leads to inhibition of tissue morphogenesis and cell differentiation (Hebrok, 2003). There is actually another transcription factor expressed throughout the posterior foregut called PDX1, and pancreatic development only initiates in the PDX1-expressing posterior foregut region where hedgehog signaling is repressed (Kim & Melton, 1998). However, this only applies during the early stages of pancreas development because SHH signaling is still required to maintain the endocrine functions of a mature pancreas (Hebrok, 2003).
References:
Hebrok, M. (2003). Hedgehog signaling in pancreas development. Mechanisms of Development, 120(1), 45–57. https://doi.org/10.1016/S0925-4773(02)00331-3
Kim, S. K., & Melton, D. A. (1998). Pancreas development is promoted by cyclopamine, a Hedgehog signaling inhibitor. Proceedings of the National Academy of Sciences, 95(22), 13036–13041. https://doi.org/10.1073/pnas.95.22.13036
Unlike in other gut regions, expression of hedgehog signaling during pancreatic development leads to inhibition of tissue morphogenesis and cell differentiation (Hebrok, 2003). There is actually another transcription factor expressed throughout the posterior foregut called PDX1, and pancreatic development only initiates in the PDX1-expressing posterior foregut region where hedgehog signaling is repressed (Kim & Melton, 1998). However, this only applies during the early stages of pancreas development because SHH signaling is still required to maintain the endocrine functions of a mature pancreas (Hebrok, 2003).
References:
Hebrok, M. (2003). Hedgehog signaling in pancreas development. Mechanisms of Development, 120(1), 45–57. https://doi.org/10.1016/S0925-4773(02)00331-3
Kim, S. K., & Melton, D. A. (1998). Pancreas development is promoted by cyclopamine, a Hedgehog signaling inhibitor. Proceedings of the National Academy of Sciences, 95(22), 13036–13041. https://doi.org/10.1073/pnas.95.22.13036