Course Guide
3. Weekly Schedule
The table below shows in which weeks and sessions specific modules will be taken up.
|
Week No. |
Topic |
Topic Outcome |
Time Frame (hr) |
Learning Activities |
Learning Resources |
|
1 |
Orientation
Introduction to Biochemistry
Buffers - Definition of acid, bases, pH, pKa - Henderson-Hasselbalch equation - Titration curves |
- Relate biochemistry to the life sciences, particularly of biology and medicine
- Explain how buffers work in biological systems
- Solve problems on buffers
|
1.0
0.5
|
Synchronous through Zoom or other online meeting platform
Watch video/ Read module
Problem solving exercises
|
- Online Videos/ References - Lectures - Modules - Textbooks
|
|
Amino Acids and pI |
- Explain the physiological and chemical properties of amino acids especially their function as biological buffers - Classify the amino acids according to their structures and properties |
1.5 |
Watch video/ read module
Solve problems and exercises |
- Online Videos/ References - Lectures - Modules - Textbooks |
|
|
2 |
Proteins: Structure and Function - Peptide bond - Levels of protein organization (collagen, hemoglobin) - Functions (catalytic, immunological, structural, etc.) |
- Explain how the nature of amino acids affect protein structure - Discuss the different functions of proteins in relation to their structures
|
1.5 |
Watch video/ Read module
Solve problems and exercises |
- Online Videos/ References - Lectures - Modules - Textbooks |
|
Proteins: Isolation and Characterization Techniques |
- Differentiate techniques in isolating and purifying proteins and their applications
|
1.5
|
Watch video/ Read module
Solve problems and exercises
|
- Online Videos/ References - Lectures - Modules - Textbooks |
|
|
3 |
Proteins: Enzymes - Classification - Kinetics (Michaelis-Menten, Lineweaver-Burk) - Inhibition (irreversible, competitive, noncompetitive, uncompetitive)
|
- Discuss the concepts of enzyme catalysis - Differentiate types of inhibitors on enzyme catalysis - Solve problems involving enzyme kinetics
|
1.5
|
Watch video/ Read module
Solve problems and exercises
|
- Online Videos/ References - Lectures - Modules - Textbooks
|
|
- Factors affecting kinetics - Minerals, coenzymes, cofactors - Multienzyme complexes (pingpong, ordered, random, sequential) |
- Differentiate enzyme and multi-enzyme complexes |
1.5
|
Watch video/ Read module
Solve problems and exercises
|
- Online Videos/ References - Lectures - Modules - Textbooks |
|
|
4 |
FIRST EXAM |
||||
|
Nucleic Acids: Structure, Properties and Function - Central dogma - RNA vs. DNA - Levels of structural organization |
- Identify the components of nucleic acids - Explain the structural differences between DNA and RNA - Describe DNA structure and how it is packed in the cell |
1.5 |
Watch video/ Read module
Solve problems and exercises
|
- Online Videos/ References - Lectures - Modules - Textbooks |
|
|
Nucleic Acids: Replication of Eukaryotes and Prokaryotes |
- Describe how a new copy of DNA is synthesized |
1.5 |
Watch video/ Read module
Solve problems and exercises
|
- Online Videos/ References - Lectures - Modules - Textbooks |
|
|
5 |
Nucleic Acids: Transcription and Post-transcriptional modification |
- Describe how RNA is synthesized from DNA - Differentiate transcription in prokaryotes and in eukaryotes - Discuss post-transcriptional modifications in eukaryotes |
1.5 |
Watch video/ Read module
Solve problems and exercises
|
- Online Videos/ References - Lectures - Modules - Textbooks |
|
Nucleic Acids: Translation in Eukaryotes and Prokaryotes
Exceptions to the central dogma - Retroviruses and reverse transcription - Epigenetics |
- Describe how protein is synthesized from mRNA - Differentiate the mechanisms of translation in eukaryotes and prokaryotes
- Explain how retroviruses utilize their genetic material
- Differentiate epigenetic and genetic effects on gene expression |
1.0
0.5 |
Watch video/ Read module
Solve problems and exercises
|
- Online Videos/ References - Lectures - Modules - Textbooks |
|
|
6 |
Nucleic Acids: Mutations and Repair - Types of mutations - Effects of physical, chemical, and viral agents - Protective and repair mechanisms |
- Assess the different mechanisms of mutation and how various agents of mutation exhibit their effects on the structure and function of nucleic acids - Explain the various protective mechanisms and repair systems in cells |
1.5 |
Watch video/ Read module
Solve problems and exercises
Look into: Chem 41\BRCA-1scenario.pdf
|
- Online Videos/ References - Lectures - Modules - Textbooks |
|
Nucleic Acids: Isolation, characterization and manipulation methods - Basic recombinant DNA techniques - Current approaches to DNA manipulation and analysis |
- Explain the techniques used in recombinant DNA technology - Discuss current approaches to DNA manipulation and analysis
|
1.5
|
Watch video/ Read module
Answer discussion questions |
- Online Videos/ References - Lectures - Modules - Textbooks |
|
|
7 |
SECOND EXAM |
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|
Carbohydrates: Structure and Function |
- Relate the structures, properties, and reactivities to the functions of carbohydrates - Draw carbohydrate structures |
1.5 |
Watch video/ Read module
Solve problems and exercises
|
- Online Videos/ References - Lectures - Modules - Textbooks |
|
|
Carbohydrates: Functions of polysaccharides |
- Differentiate the structure and function of polysaccharides |
1.5
|
Watch video/ Read module
Solve problems and exercises
|
- Online Videos/ References - Lectures - Modules - Textbooks |
|
|
8 |
Lipids: Structure and Function |
- Relate the structures and properties to the functions of lipids - Draw lipid structures - |
1.5
|
Watch video/ Read module
Solve problems and exercises
|
- Online Videos/ References - Lectures - Modules - Textbooks |
|
Biological Membranes and Membrane Transport |
- Relate membrane structure to its functions - Discuss transport mechanisms in membranes
|
1.5
|
Watch video/ Read module
Solve problems and exercises
|
- Online Videos/ References - Lectures - Modules - Textbooks |
|
|
9 |
Bioenergetics - Introduction to metabolism, stages, and regulation - Free energy, high energy compounds, and coupled reactions - Substrate level phosphorylation - Oxidative phosphorylation - Electron transport chain - Inhibitors of ATP chain - Other energy transducing reactions |
- Present an overview of metabolism - Apply the laws of thermodynamics in the maintenance of cellular functions - Discuss the methods of ATP synthesis and processes that affect it - Enumerate important biological reactions that use and produce energy |
1.5 |
Watch video/ Read module
Solve problems and exercises
|
- Online Videos/ References - Lectures - Modules - Textbooks
|
|
Carbohydrate Catabolism - Glycolysis - Kreb’s cycle - Glycogenolysis - Anaerobic respiration (ethanol fermentation, lactic acid fermentation) |
- Discuss cellular respiration as the major catabolic and energy-producing pathway of all cells - Illustrate various catabolic pathways for carbohydrates |
1.5
|
Watch video/ Read module
Solve problems and exercises
|
- Online Videos/ References - Lectures - Modules - Textbooks |
|
|
10 |
Continuing on Carbohydrate Catabolism |
|
1.5 |
Watch video/ Read module
Solve problems and exercises |
- Online Videos/ References - Lectures - Modules - Textbooks - |
|
Lipid Catabolism - Lipolysis - β-oxidation |
- Discuss the role of lipids as alternative sources of energy and the different reactions in the |
1.0 |
Watch video/ Read module
Solve problems and exercises
|
- Online Videos/ References - Lectures - Modules - Textbooks |
|
|
11 |
Amino Acid Catabolism - Transamination, oxidative deamination, direct deamination - Amino acid catabolism - Nitrogenous base catabolism - Urea cycle
Nucleic Acid Catabolism - Purine and Pyrimidine Catabolism |
- Discuss the role of amino acids as primary or alternative sources of energy - Trace the fates of the amino group and carbon skeleton of amino acids - Calculate and compare the ATP generated from various sources
- Explain nucleic acid catabolism |
2.0 |
Watch video/ Read module
Solve problems and exercises
|
- Online Videos/ References - Lectures - Modules - Textbooks |
|
THIRD EXAM |
|||||
|
Carbohydrate Anabolism - Gluconeogenesis - Glycogenesis and regulatory enzymes - Pentose phosphate pathway |
- Discuss the pathways leading to the synthesis of glucans and glucose |
1.5 |
Watch video/ Read module
Solve problems and exercises
|
- Online Videos/ References - Lectures - Modules - Textbooks |
|
|
12 |
Lipid Anabolism - Biosynthesis of fatty acids - Lipogenesis - Ketogenesis - Biosynthesis of cholesterol and eicosanoids - Lipid transport: HDL, LDL, VLDL, chylomicrons |
- Present the pathways that cells undergo in order to synthesize fatty acids - Discuss the pathways that liver cells undergo to compensate for the decrease in dietary sources of energy - Explain the reactions leading to cholesterol synthesis and how these processes are regulated |
1.5 |
Watch video/ Read module
Solve problems and exercises
|
- Online Videos/ References - Lectures - Modules - Textbooks |
|
Nitrogen Anabolism - Biosynthesis of amino acids - De novo and salvage pathways of nitrogenous bases |
- Summarize the precursors and pathways leading to the synthesis of amino acids and nucleotides |
1.5
|
Watch video/ Read module
Solve problems and exercises
|
- Online Videos/ References - Lectures - Modules - Textbooks |
|
|
13 |
Integration - Digestion and Absorption of Foodstuffs - Metabolic Patterns in Animals (e.g. plasma levels of glucose, fatty acids and ketone bodies) - Integration and Regulation of Metabolic Pathways |
- Correlate the various metabolic pathways - Compare the levels of metabolites during the different stages of metabolism - Differentiate metabolic needs of various organ systems - Discuss how various metabolic pathways are regulated |
3.0
|
Watch video/ Read module
Solve problems and exercises
|
- Online Videos/ References - Lectures - Modules - Textbooks |
|
|
FOURTH EXAM |
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|
14 |
FINAL EXAM |
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You can also download this table here.