Section outline

  • In this topic, we will discuss the principles of cancer genetic risk assessment with the clinical practice guidelines from the National Society of Genetic Counselors and the National Comprehensive Cancer Network as references. We will also tackle the issues surrounding cancer genetic testing, informed consent, and provision of psychosocial support specific to cancer genetics. For this topic, we will specifically tackle hereditary breast and ovarian cancer and Lynch Syndrome as examples. 

    • NSGC Recommendations for Cancer Genetics Assessment, Counseling, and Testing File

      This recommendations paper by the NSGC discusses essential information about cancer assessment, genetic testing, informed consent, and psychosocial support.

    • NCCN Practice Guidelines on Genetic Assessment for Colorectal Cancer File

      This recent document elaborates on the current guidelines on hereditary colorectal cancer assessment. This features algorithms in risk assessment, genetic testing, and surveillance recommendations. 

    • NCCN Practice Guidelines on Genetic Assessment of Breast, Ovarian, and Pancreatic Cancer File

      This recent document elaborates on the genetic assessment of hereditary breast, ovarian, and pancreatic cancers. This also contains algorithms in assessment, genetic testing, and surveillance recommendations. 

    • BRCA1 and BRCA2 mutations and hereditary breast and ovarian cancer File

      Majority of cases of hereditary breast and ovarian cancer are due to mutations in either the BRCA1 or the BRCA2 gene. This review papers elucidates on the role of mutations in the BRCA1 and BRCA2 genes in hereditary breast and ovarian cancer. 

    • Breast cancer risk assessment models File

      There are a number of breast cancer risk assessment models that can be used with their pros and cons. This paper elaborates on the advantages and disadvantages of each of the breast cancer risk assessment models available. 

    • Myriad BRCA Prevalence Table File

      Myriad has for the longest time 'owns' the patent for the BRCA1 and BRCA2 genes. Through their research, they have developed the prevalence risk tables which tells the probability of a mutation in either the BRCA1 or BRCA2 gene given features in the family health history. 

    • PREMM5 Lynch Syndrome Assessment Model URL

      This prediction model developed by Dana-Farber Cancer Institute utilizes information from the family history to predict probability of mutations in any of the mismatch repair genes which is causative of Lynch Syndrome. 

    • Genetic Counseling in Hereditary Colorectal Cancer URL

      Watch this prerecorded video on genetic counseling approaches in hereditary colorectal cancer. 

    • Cancer Genetic Counseling PPT URL

      You can download here the powerpoint presentation of Dr. Tumulak on cancer genetic counseling.